SLU-PP-332 is a synthetic small-molecule compound under investigation for its capacity to function as an exercise mimetic through selective activation of estrogen-related receptors (ERRs), a family of orphan nuclear receptors that play a central role in metabolic regulation. As a pan-agonist for all three ERR isoforms—ERRα, ERRβ, and ERRγ—SLU-PP-332 exhibits its greatest potency toward ERRα, a key transcriptional regulator of mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation. Activation of ERR signaling by SLU-PP-332 enhances the transcription of gene networks associated with increased cellular energy expenditure and improved mitochondrial function, closely paralleling the molecular adaptations induced by sustained aerobic exercise. Preclinical research has therefore focused on its potential therapeutic utility in conditions characterized by impaired metabolic flexibility, including obesity, type 2 diabetes, and cardiac dysfunction such as heart failure. Early findings suggest that ERR activation may improve metabolic efficiency, promote enhanced oxidative capacity in skeletal and cardiac muscle, and modulate systemic glucose and lipid homeostasis, positioning SLU-PP-332 as a promising investigational platform for metabolic disease interventions. Ongoing studies aim to further elucidate its pharmacodynamics, tissue specificity, and long-term effects on metabolic and mitochondrial pathways.

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Ingredients: SLU-PP-332 5mg

Type: Mitochondrial peptide

Form: Lyophilized powder 

Purity: ≥99% (HPLC)

Storage: Store at 2–8 °C, protected from light and moisture

For research purposes only.